Previous Clinical Research

Studies Involving Patients

Alzheimer's disease

• First administration to patients
• Pharmacokinetics and tolerability
• Short & long-term efficacy and tolerability
• Pharmocokinetics of once versus twice daily dosing
  
• Double blind efficacy studies
• Open label extension studies
• Acetylcholinesterase inhibitors
• Muscarinic agonists
• Nicotinic agonists
• 5-HT3 antagonists
• NMDA receptor modulators
  
• Glial cell modulators
• Amyloid immunisation
• Monoclonal antibodies
  
• Gamma secretase inhibitors
  

Mild Cognitive Impairment

• NMDA receptor modulators
  
• Acetylcholinesterase inhibitors

Vascular dementia

• Vasodilators
• Glutamatergic modulators
• Acetylcholinesterase inhibitors
• Glial cell modulators

Parkinson's disease

• COMT inhibitor
• Acetylcholinesterase inhibitors

Studies Involving Healthy Subjects

• Bioavailability (relative & absolute) & bioequivalence

• Interaction Studies:
  

• Pharmacokinetics