Previous Research
Studies Involving Patients
Alzheimer's disease
- First administration to patients
- Pharmacokinetics and tolerability
- Double blind efficacy studies
- Open label extension studies
- Acetylcholinesterase inhibitors
- Muscarinic agonists
- Nicotinic agonists
- 5-HT3 antagonists
- NMDA receptor modulators
- Amyloid immunisation
- Glial cell modulators
- Statins
Mild Cognitive Impairment
- Acetylcholinesterase inhibitors
- Ampakine
- AMPA- type glutamate receptor modulator
Vascular dementia
- Vasodilators
- Glutamatergic modulators
- Acetylcholinesterase inhibitors
- Glial cell modulators
Parkinson's disease
Age-related memory problems
Studies Involving Healthy Subjects (Young, Old, Postmenopausal)
Bioavailability (relative & absolute) & bioequivalence
- A nonsteroidal tablet vs dispersible formulation
- An H2 antagonist IV vs oral comparison
Interaction studies
- Food: with an antidementia drug in elderly subjects
- Food: with a nonsteroidal in elderly subjects
- Diuretic: with a nonsteroidal in elderly subjects
- Warfarin: with a nonsteroidal in young subjects
- Digoxin: with an antipsychotic in elderly subjects
- Alcohol: with an antidementia drug in elderly subjects
- Glyceryl trinitrate: with a phosphodiesterase inhibitor in elderly subjects
Pharmacokinetics
- Single / multiple dose kinetics
- Dose linearity
- Oral/topical / IM / IV bolus or infusion
- An antidementia drug in young and old subjects
- A nonsteroidal gel in young and old subjects
- An anti-obesity drug in young and old subjects
- An alpha blocker comparing bd vs tds doses
- An antidementia drug comparing bd vs tds doses
- An antifungal in elderly subjects
- A nonsteroidal in elderly subjects
Special studies
- Scopolamine model for antidementia drugs - young/old subjects
- Activity monitoring (indirect but useful measure of sleep)
- Gastric emptying studies
- Acetylator / hydroxylator status etc
- Measuring nicotinic receptors on blood cells in older adults